Central San Diego Vacation Rentals

Compare Vacation Rentals & Rent By Owner Homes in Central San Diego, California, USA

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10.0 (10 Reviews)
2 Bedrooms 6 Guests
New NEW LUX Modern Retreat | Views | Parking | Workspaces
New Large Backyard w/Firepit and Grill | Pet Friendly
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10.0 (4 Reviews)
3 Bedrooms 8 Guests
From ZA R2,098 per night
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9.8 (9 Reviews)
1 Bedroom 2 Guests
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10.0 (4 Reviews)
1 Bedroom 3 Guests
From ZA R16,198 per night
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10.0 (3 Reviews)
4 Bedrooms 10 Guests
New 3BR+2BA | Hot Tub | Tropical Oasis
New
4 Bedrooms 11 Guests
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10.0 (3 Reviews)
1 Bedroom 2 Guests
New 10 Min to the Zoo and Beach! | Tropical Townhome
New
4 Bedrooms 10 Guests
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10.0 (2 Reviews)
4 Bedrooms 10 Guests
New 6 Mi to Pacific Beach: Pet-Friendly San Diego Home
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10.0 (2 Reviews)
4 Bedrooms 12 Guests
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10.0 (2 Reviews)
2 Bedrooms 7 Guests
New Superb 3-bedroom remodeled condo in sunny San Diego
10.0 (2 Reviews)
2 Bedrooms 4 Guests
10.0 (2 Reviews)
2 Bedrooms 4 Guests
From ZA R21,079 per night
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10.0 (1 Review)
4 Bedrooms 8 Guests
New Hip Walkable Neighborhood: Condo in San Diego
New
2 Bedrooms 4 Guests
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10.0 (1 Review)
1 Bedroom 8 Guests
New NEWLY Built, Private studio w/separate entrance
New
1 Bedroom 4 Guests
From ZA R14,134 per night
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10.0 (1 Review)
3 Bedrooms 8 Guests
New Enjoyable studio with AC in sunny San Diego
New
1 Bedroom 3 Guests
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10.0 (1 Review)
4 Bedrooms 10 Guests
New Top-Floor Oasis - Bright, Private, Pool & Gym
From ZA R10,960 per night
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10.0 (1 Review)
4 Bedrooms 12 Guests
New Calm North Park Condo - Parking/Jacuzzi/Walkable
New
2 Bedrooms 6 Guests
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10.0 (1 Review)
3 Bedrooms 8 Guests
New Cozy 1-bedroom in great central location in San Diego
New Sunlit ADU near SDSU!
From ZA R1,961 per night
New
1 Bedroom 2 Guests
10.0 (78 Reviews)
1 Bedroom 2 Guests
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10.0 (1 Review)
3 Bedrooms 10 Guests
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10.0 (1 Review)
3 Bedrooms 8 Guests
From ZA R3,122 per night
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7.6 (4 Reviews)
1 Bedroom 2 Guests
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10.0 (1 Review)
3 Bedrooms 8 Guests
New
2 Bedrooms 6 Guests
From ZA R6,257 per night
10.0 (57 Reviews)
2 Bedrooms 4 Guests
From ZA R6,018 per night
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10.0 (1 Review)
1 Bedroom 4 Guests
10.0 (55 Reviews)
1 Bedroom 4 Guests
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10.0 (1 Review)
1 Bedroom 10 Guests
10.0 (55 Reviews)
1 Bedroom 4 Guests
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10.0 (1 Review)
1 Bedroom 2 Guests
10.0 (54 Reviews)
2 Bedrooms 4 Guests
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10.0 (1 Review)
1 Bedroom 4 Guests
10.0 (1 Review)
1 Bedroom 12 Guests
From ZA R4,388 per night
10.0 (1 Review)
1 Bedroom 2 Guests
From ZA R4,446 per night
10.0 (48 Reviews)
2 Bedrooms 6 Guests
10.0 (1 Review)
1 Bedroom 6 Guests
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9.9 (26 Reviews)
4 Bedrooms 8 Guests

About Central San Diego Vacation Rentals

With more than 3248 Central San Diego vacation rentals, we can help you find a place to stay. These rentals, including vacation rentals, Rent By Owner Homes (RBOs) and other short-term private accommodations, have top-notch amenities with the best value, providing you with comfort and luxury at the same time. Get more value and more room when you stay at an RBO property in Central San Diego.

Looking for last-minute deals, or finding the best deals available for cottages, condos, private villas, and large vacation homes? With RentByOwner Central San Diego, you have the flexibility of comparing different options of various deals with a single click. Looking for an RBO with the best swimming pools, hot tubs, allows pets, or even those with huge master suite bedrooms and have large screen televisions? You can find vacation rentals by owner (RBOs), and other popular Airbnb-style properties in Central San Diego. Places to stay near Central San Diego are 655.62 ft² on average, with prices averaging ZA R6,061 a night.

RentByOwner makes it easy and safe to find and compare vacation rentals in Central San Diego with prices often at a 30-40% discount versus the price of a hotel. Just search for your destination and secure your reservation today.

Frequently Asked Questions About Central San Diego?

What are the top vacation rentals in Central San Diego?

How many Rentbyowner vacation rentals are available in Central San Diego?

Currently, the total number of properties listed by Rent By Owner in 2025 is over 3248 in the Central San Diego area, and still counting. By aggregating listings from multiple websites, Rent By Owner offers an immense amount of choice of the best RBO properties in Central San Diego. 

Nearby Neighborhood (16)

Neighborhood Property Count
Downtown San Diego Vacation Rentals in San Diego, California 1141
Point Loma Vacation Rentals in San Diego, California 744
North Park Vacation Rentals in San Diego, California 174
Mission Valley Vacation Rentals in San Diego, California 174
Hillcrest Vacation Rentals in San Diego, California 137
Little Italy Vacation Rentals in San Diego, California 120
Clairemont Vacation Rentals in San Diego, California 90
Bay Park Vacation Rentals in San Diego, California 89
University City Vacation Rentals in San Diego, California 82
San Carlos Vacation Rentals in San Diego, California 76
Golden Hill Vacation Rentals in San Diego, California 69
Mira Mesa Vacation Rentals in San Diego, California 58
Old Town Vacation Rentals in San Diego, California 48
Serra Mesa Vacation Rentals in San Diego, California 37
Sorrento Valley Vacation Rentals in San Diego, California 26
Kearny Mesa Vacation Rentals in San Diego, California 103